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Thursday, February 28, 2013

Heamoliphia

haemophilia
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Haemophilia|
potpourri and external resources|

Deficiency in coagulation factor  octet is the approximately ballpark cause of bleeders disease.|
ICD-10| D66-D68|
ICD-9| 286|
OMIM| 306700 306900 264900|
DiseasesDB| 5555 5561 29376|
MedlinePlus| 000537|
eMedicine| med/3528|
MeSH| D025861|

Haemophilia ( /hi?m??f?li?/; also spelled hemophilia in North America, from the Greek haima ???? blood and philia ????? love[1]) is a group of hereditary heritable disorders that impair the bodys ability to control blood clotting or coagulation, which is used to stop bleeding when a blood vessel is broken. Haemophilia A (clotting factor VIII deficiency) is the most common form of the disorder, present in about 1 in 5,00010,000 male births.[2] Haemophilia B (factor IX deficiency) deceases in rough 1 in about 20,00034,000 male births.
Like most recessive sex-linked, X chromosome disorders, haemophilia is more likely to occur in males than females. This is because females obtain two X chromosomes while males go for only one, so the defective constituent is guaranteed to manifest in any male who carries it.

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Because females have two X chromosomes and haemophilia is rare, the chance of a female having two defective copies of the gene is very remote, so females are almost exclusively well carriers of the disorder. Female carriers toilette inherit the defective gene from all their mother or father, or it may be a new mutation. Although it is not impossible for a female to have haemophilia, it is unusual: a female with haemophilia A or B would have to be the daughter of both a male haemophiliac and a female carrier, while the non-sex-linked haemophilia C due to coagulant factor XI deficiency, which can affect either sex, is more common in Jews of Ashkenazi (east European) melodic phrase but rare in other population groups.
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